Night Shift Rx - Hormonal Acne Serum
Tailored Tretinoin
$78 Trial Offer
Trial offer 2-month supply
Free Shipping
Free Shipping
200+ 5⭐ Reviews
Prescription strength retinoid for hormonal acne online
Tailored formula with Tretinoin, Niacinamide, Spironolactone, and Clindamycin
Developed by board-certified dermatologists for personalized, expert care
Targets fine lines, wrinkles, hormonal acne, dark spots, uneven skin tone, and large pores
Get a prescription online, no need to visit a doctor’s office
Fill out your skin profile, upload photos, and receive a custom formula from a medical provider
Your first bottle lasts ~2 months; refills last ~3 months and bill at $117 every quarter
Pause, skip, or cancel anytime with just a few clicks
*At checkout, answer questions and upload photos of your skin for your provider to determine if a prescription is appropriate.
Tretinoin Face Prescription Online
First-time bottle lasts ~2 months. Refills last ~3 months and bill at $99/quarter. Change frequency or cancel anytime.
Enjoy the ease of an online dermatologist review and get your Tretinoin, a prescription strength retinoid online.
Bonus ingredient: Niacinamide, an anti-inflammatory healing compound that calms redness and boosts hydration.
Treats acne, including hormonal acne
The combination of Tretinoin, Spironolactone, and Clindamycin is known to support the root causes of acne — excess oil production, clogged pores, and acne-causing bacteria — helping to reduce hormonal acne breakouts.
Helping to reduce fine lines & wrinkles; Tretinoin is the gold-standard, FDA-approved ingredient for photoaging — it helps increase cell turnover to smooth fine lines and improve skin texture.
Tretinoin helps improve skin texture and promotes even skin tone by accelerating skin cell renewal.
Tretinoin and Niacinamide work synergistically to help fade hyperpigmentation and improve radiance.
Niacinamide helps calm inflammation, soothes irritation and helps strengthen the skin barrier, making it more tolerable than traditional single-ingredient Tretinoin.
Spironolactone works at the hormonal level to helps to control excess oil, prevent clogged pores and reduce sebum (oil) production — and especially helps with hormonal or cystic acne.
Clindamycin is an antibiotic that helps reduce Propionibacterium acnes bacteria on the skin, a key factor in inflammatory acne.
As easy as 1-2-3.
Get a tailored solution from our dermatologist partners to match your unique skin profile – gentle enough for even the most sensitive skin.
STEP 1
Share your skin goals
No need for an in-person visit to the
dermatologist. In just a few minutes, share details about your skin and upload photos on our secure telehealth portal.
dermatologist. In just a few minutes, share details about your skin and upload photos on our secure telehealth portal.
STEP 2
Our doctors tailor your formula
You are unique and your skin is too. A doctor will review your profile and tailor your derm-strength Night Shift serum to create a formula just for you.
STEP 3
Check in with your skin coach
Like any fitness routine, retinoids work best by starting out slowly. Your provider is available at any time to check in and assess your progress.
Ingredients
Spironolactone
Spironolactone helps combat hormonal acne by blocking androgen receptors, which helps reduce excess sebum, minimizes breakouts, and improves skin texture.
Clindamycin
Clindamycin helps treat acne by targeting the bacteria that contribute to breakouts and reducing inflammation. It works by slowing or stopping the growth of acne-causing bacteria on the skin while decreasing swelling. This results in fewer breakouts, less redness, and an overall improvement in skin appearance.
Tretinoin
Tretinoin is a prescription-strength retinoid that increases skin cell turnover and stimulates collagen production. It helps reduce the appearance of fine lines and wrinkles, improve uneven skin tone and texture, and address other visible signs of skin aging.
Niacinamide
Niacinamide is a multitasking skincare ingredient that helps support the skin barrier, improve moisture retention, and reduce the appearance of redness and uneven skin tone. It pairs especially well with Tretinoin, helping support skin comfort when using a powerful retinoid like Tretinoin that can sometimes cause dryness and irritation.
Spironolactone, Clindamycin, Tretinoin, Niacinamide, ST-Elastomer 10, Q7-9120 Silicone Fluid, EL-7040 Hydro Elastomer Blend, Vitamin E Acetate, Liquid, Polyglycerol-3 Diisostearique.
ALCOHOL FREE
CRUELTY FREE
FRAGRANCE FREE
PARABEN FREE
Night Shift for anyone and everyone.
Whether you have sensitive or dry skin, or whether you’re a retinoid rookie or not, our Board-certified doctors got you. Understanding that everyone's skin is different, they provide you with an appropriate strength of our tailored Tretinoin prescription for your specific skin type.
At Dear Brightly we are committed to giving you a better overall retinoid experience.
ADD TO CARTAt Dear Brightly we are committed to giving you a better overall retinoid experience.
Start seeing results as early as 2 weeks.*
Practice makes progress! Start slowly, be patient, and watch your skin transform. Collagen isn’t built in a day, so we’ve made sure you’ve got the right routine for the journey. And we’re here to be your coach, teammate, and biggest fan – every step of the way.
*Individual results may vary
*Individual results may vary
1-2 weeks
Brightens and reduces uneven skin tone.
2-4 weeks
Discoloration is improved.
4-6 weeks
Brown spots diminish.
3-6 months
Reduced fine lines and wrinkles.
6 months - 1 year
Clear, radiant skin
The Power of Rx Retinoids.
Yes — when paired with ingredients like spironolactone and clindamycin, tretinoin can effectively address hormonal acne. This combination works by lowering excess oil production, targeting acne-causing bacteria, and calming inflammation. Together, these benefits lead to clearer skin, reduced redness, and a healthier overall complexion
Retinoids help your skin produce more collagen, which can reduce the look of fine lines and wrinkles. They also encourage the growth of new blood vessels, giving your complexion a healthy, rosy glow.
Retinoids help unclog the buildup around enlarged pores, making them look smaller and helping keep them clear over time.
Retinoids are one of the most effective ways to treat and prevent blackheads. They work by reducing clogged pores and the early stages of acne, helping minimize both inflammatory and non-inflammatory breakouts.
Persistent acne that resists standard treatments may benefit from topical tretinoin available via online prescription. By clearing clogged pores, retinoids enhance the skin’s ability to absorb other topical therapies.
Topical retinoids help exfoliate the skin, which supports the natural removal of milia. They also smooth rough texture by shedding dead skin cells and boosting glycosaminoglycan (GAG) production.
Retinoids aren’t a fix for all types of hyperpigmentation, but they can help fade freckles, melasma, sun spots, and dark marks by breaking up melanin clusters in the skin.
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